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Alto Neuroscience announced on October 22, 2024, that “the Phase 2b study of ALTO-100 in patients with major depressive disorder (MDD) did not meet its primary endpoint, assessed by a change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS), compared to placebo.”
Following this news, shares of Alto Neuroscience fell over 60% in after hours trading on the same day.